Video Experimental Relacionado
Updated: Jan 13, 2026
09:14
Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
4.5K
Colitis por el virus de Epstein-Barr sobre un fondo de enfermedad de Crohn
Zane Attard1, Matthias Barbara2, Elizier Zahra Bianco3
1Medicine, Mater Dei Hospital, Msida, Malta zaneattard@outlook.com.
BMJ case reports
|January 9, 2026
Resumen
Este estudio de caso destaca la reactivación del virus de Epstein-Barr (VEB) en un paciente con enfermedad inflamatoria intestinal (EII). La monitorización de la carga viral del VEB es crucial para tratar eficazmente los casos de EII refractaria.
Área de la Ciencia:
- Gastroenterología
- Virología
- Inmunología
Sus antecedentes:
- El manejo de la enfermedad inflamatoria intestinal (EII) puede ser complejo, especialmente en casos con síntomas refractarios.
- La reactivación del virus de Epstein-Barr (VEB) es una preocupación emergente en pacientes inmunocomprometidos, incluidos aquellos con EII.
Objetivo del estudio:
- Presentar un caso de EII refractaria potencialmente asociada con la reactivación del VEB.
- Explorar el papel de la monitorización de la carga viral del VEB en la toma de decisiones de tratamiento para casos complejos de EII.
Principales métodos:
- Un informe de caso que detalla una mujer de mediana edad con antecedentes de EII.
- Colonoscopia con prueba de PCR para detectar ADN del VEB en tejido inflamado.
- Ajustes del tratamiento que incluyen esteroides, azatioprina, infliximab y vedolizumab.
- Monitorización terapéutica de fármacos para infliximab.
Principales resultados:
- Se detectaron niveles elevados de ADN del VEB (6961 copias/mL) en el tejido colónico inflamado.
- La inmunosupresión inicial proporcionó un alivio parcial, pero la azatioprina se suspendió debido a efectos adversos.
- A pesar de la disminución del ADN del VEB, el tratamiento con infliximab fracasó, lo que obligó a cambiar a vedolizumab.
- El vedolizumab demostró una buena respuesta clínica en este paciente con EII refractaria.
Conclusiones:
- La monitorización rutinaria de la carga viral del VEB puede ser beneficiosa en pacientes con EII refractaria.
- El manejo de la colitis asociada al VEB en la EII requiere una cuidadosa consideración de las estrategias de inmunosupresión.
- Este caso destaca los desafíos y las posibles vías terapéuticas en casos complejos de EII con coinfecciones virales.
Videos de Conceptos Relacionados
01:30Inflammatory Bowel Disease II: Crohn's Disease
945
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
945
01:17Chronic Bowel Disorders: Introduction
743
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
743
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
882
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
882
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
480
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
480
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
631
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
631
01:17Gastritis-II: Pathophysiology
1.2K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.2K