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Estrategias emergentes no antibióticas para infecciones de biofilm asociadas a implantes mediante la reprogramación

Yu Zhang¹, Zhuo Dai¹, Xiaoye Li¹

¹Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, Jiangsu, China.

NPJ biofilms and microbiomes

|January 9, 2026

Abstract:

Implant-associated infections (IAIs) arise from immune dysregulation and the resilience of bacterial biofilms, which create a permissive niche for persistent infection. Biofilms further suppress host immunity and impair repair. Advances in nanoengineered surfaces and multifunctional antimicrobial coatings, together with gas-releasing and stimulus-responsive nanoplatforms, offer effective non-antibiotic strategies to inhibit colonization, disrupt biofilms, and modulate local immunity. This review summarizes emerging immune-informed approaches for treating IAIs.

Palabras clave:

nanotecnología infecciones asociadas a implantes biofilms modulación inmunitaria terapias no antibióticas

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