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Mensajeros Metabólicos: testosterona

Franck Mauvais-Jarvis1,2, Shalender Bhasin3

  • 1Hormone Therapy Clinic, Medicine Service, Southeast Louisiana New Orleans VA Medical Center, New Orleans, LA, USA. fmauvais@tulane.edu.

Nature metabolism
|January 9, 2026
PubMed
Resumen
Este resumen es generado por máquina.

La testosterona es una hormona vital para ambos sexos, que actúa directa e indirectamente para regular el metabolismo. Su descubrimiento y síntesis revolucionaron la terapia de reemplazo hormonal y continúan siendo cruciales para la homeostasis metabólica.

Palabras clave:
testosteronametabolismohomeostasis metabólicaterapia de reemplazo hormonal

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Área de la Ciencia:

  • Endocrinología
  • Ciencia Metabólica
  • Biología Hormonal

Sus antecedentes:

  • La testosterona, sintetizada en la década de 1930, es la primera hormona utilizada para la terapia de reemplazo.
  • Funciona a través de receptores de andrógenos (AR) y como prohormona del estrógeno.
  • Los metabolitos de la testosterona, como la dihidrotestosterona, también desempeñan papeles importantes.

Objetivo del estudio:

  • Revisar los hitos históricos en el descubrimiento de la testosterona y sus usos terapéuticos.
  • Sintetizar el conocimiento actual sobre el papel de la testosterona en la regulación metabólica.
  • Destacar la importancia de la testosterona en el mantenimiento de la homeostasis metabólica.

Principales métodos:

  • Revisión histórica del descubrimiento y las aplicaciones de la testosterona.
  • Síntesis de estudios preclínicos y en humanos sobre las funciones metabólicas de la testosterona.
  • Análisis de las vías de señalización, incluidos los receptores de andrógenos y estrógenos.

Principales resultados:

  • La testosterona impacta el metabolismo a través de vías directas e indirectas.
  • Los metabolitos como el estradiol y la dihidrotestosterona son mediadores cruciales.
  • Las acciones genómicas y no genómicas de la testosterona y sus metabolitos están involucradas.

Conclusiones:

  • La testosterona es esencial para la homeostasis metabólica tanto en hombres como en mujeres.
  • Comprender los roles multifacéticos de la testosterona es fundamental para las aplicaciones terapéuticas.
  • La investigación en curso continúa revelando la importancia metabólica sistémica de la testosterona.