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Epigenética y el Microambiente Tumoral en Tumores Neuroendocrinos

Alice Castenetto¹, Teresa Gagliano¹

¹Cancer Cell Signalling Lab, Department of Medicine, University of Udine, 33100 Udine, Italy.

|January 10, 2026

Resumen

La regulación epigenética y el microambiente tumoral son clave en el desarrollo y progresión de las neoplasias neuroendocrinas (NEN). La comprensión de estos factores puede conducir a nuevas estrategias terapéuticas para las NEN.

Área de la Ciencia:

Oncología
Epigenética
Biología del Cáncer

Sus antecedentes:

Las neoplasias neuroendocrinas (NEN) son cánceres diversos, a menudo con bajas tasas de mutación.
El enfoque se está desplazando hacia los mecanismos epigenéticos y el microambiente tumoral en la patogénesis de las NEN.
Las modificaciones epigenéticas pueden mediar la comunicación entre las células NEN y su microambiente.

Objetivo del estudio:

Revisar el papel de la regulación epigenética en la patogénesis de las NEN.
Resumir el impacto del microambiente tumoral en las NEN.
Explorar posibles dianas terapéuticas dentro de estos mecanismos.

Principales métodos:

Revisión exhaustiva de la literatura sobre NEN.
Análisis de estudios que investigan mecanismos epigenéticos.
Examen de las interacciones del microambiente tumoral en las NEN.

Principales resultados:

Las alteraciones epigenéticas influyen significativamente en el desarrollo y la progresión de las NEN.
Las interacciones del microambiente tumoral son cruciales para la biología de las NEN.
Estos factores impactan la respuesta terapéutica en tumores neuroendocrinos.

Conclusiones:

Se necesita más investigación para comprender completamente la patogénesis de las NEN.
Una comprensión más profunda puede impulsar el desarrollo de terapias más efectivas.
Este conocimiento promete mejores resultados para los pacientes con NEN.

Palabras clave:

cruce epigenética neoplasias neuroendocrinas dianas estrategias terapéuticas microambiente tumoral

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