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Homeostasis Coclear en la Hipoacusia Neurosensorial: Mecanismos, Implicaciones y Perspectivas Terapéuticas
Srdjan M Vlajkovic1,2, Haruna Suzuki-Kerr1,2, Bryony A Nayagam3
1Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand.
International journal of molecular sciences
|January 10, 2026
Resumen
Mantener la homeostasis coclear es vital para la audición. Las interrupciones provocan hipoacusia neurosensorial, pero las nuevas terapias buscan la reparación regenerativa y la recuperación de la audición.
Área de la Ciencia:
- Oto-neurología
- Biología celular
- Biología molecular
Sus antecedentes:
- La homeostasis coclear preserva la sensibilidad auditiva al regular el líquido coclear, los gradientes electroquímicos y la función celular.
- La hipoacusia neurosensorial (SNHL) está relacionada con interrupciones en el entorno homeostático de la cóclea.
- El daño a las células ciliadas, las neuronas auditivas y otras estructuras cocleares contribuye a la SNHL.
Objetivo del estudio:
- Explorar las vías celulares y moleculares de la homeostasis coclear en la salud y la enfermedad.
- Examinar cómo la homeostasis fallida causa SNHL.
- Discutir las estrategias terapéuticas emergentes para restaurar el equilibrio homeostático.
Principales métodos:
- Este estudio es una revisión narrativa.
- Sintetiza la investigación actual sobre la homeostasis coclear y la SNHL.
- Examina los mecanismos celulares y moleculares subyacentes.
Principales resultados:
- Las interrupciones en la homeostasis coclear son un factor clave en la SNHL.
- La comprensión de estas interrupciones revela vías que conducen a la pérdida de audición.
- La investigación actual se centra en restaurar el equilibrio homeostático.
Conclusiones:
- La homeostasis coclear fallida es una causa principal de SNHL.
- Las estrategias terapéuticas emergentes ofrecen esperanza para la curación regenerativa.
- Las intervenciones futuras pueden conducir a la reparación permanente y la recuperación funcional de la audición.
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