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A Contusion Model of Severe Spinal Cord Injury in Rats
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Respuestas inmunitarias en el microambiente después de una lesión de la médula espinal: un estudio bibliométrico de
Yang Zhou1, Li-Min Mou2, Dao-Xin Zhang1
1Department of Orthopedics, Affiliated Renhe Hospital of China Three Gorges University, Yichang, Hubei Province, China.
Objective:
To analyze the current research status, hotspots and development trends in the field of immune response in the microenvironment after spinal-cord injury (SCI).
Methods:
From January 1, 2005 to December 31, 2024, the literatures about immune response in microenvironment after SCI were retrieved from the core collection of Web of Science. The authors, countries, institutions, journals, co-cited literatures and keywords included in the literatures were visually analyzed by VOS viewer and bibliometrix, and the knowledge map was drawn.
Results:
Analysis of 443 papers identified China and the US as leading contributors. Popovich PG emerged as a highly influential author, with the University of California System being the most productive institution. Key journals include Journal of Neuroinflammation and Brain Behavior and Immunity. Research hotspots center on macrophages, inflammation, and neutrophils, with microglia and central-nervous-system regulation playing significant roles in post-injury immune response.
Conclusion:
Immune responses within the SCI microenvironment are a major research focus, shifting from mechanistic studies towards immunoregulatory strategies, aided by promising new technologies. Future progress requires enhanced multi-institutional collaboration and information sharing to accelerate research translation and improve patient recovery.
