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Actividad antibacteriana de nuevos derivados de azol que incorporan Etodolac

Zahraa N Fakhreldain¹, Hajer A Jawad², Israa Sami Hadi²

¹DEPARTMENT OF CLINICAL PHARMACY, FACULTY OF PHARMACY, UNIVERSITY OF KUFA, NAJAF, IRAQ.

Wiadomosci lekarskie (Warsaw, Poland : 1960)

|January 10, 2026

Abstracto

Objective:

Aim: This research paper investigates the synthesis and antibacterial activity of novel azole derivatives incorporating Etodolac.

Patients And Methods:

Materials and Methods: The study focused on the reaction of Etodolac with three different aromatic amines: o-phenylene diamine, 2-aminophenol, and 2-aminothiophenol, resulting in three new compounds (1-3). The antibacterial activity of these compounds was assessed against Escherichia coli, Klebsiella, Staphylococcus aureus, and Streptococcus mutans.

Results:

Results: Compound 1 demonstrated the most potent antimicrobial activity against all four bacteria, exhibiting a remarkably low MIC against Escherichia coli.

Conclusion:

Conclusions: The results of this research suggest that incorporating Etodolac into the synthesis of azole derivatives can lead to potent antimicrobial agents. Further exploration of these compounds is warranted to fully understand their potential therapeutic applications.

Palabras clave:

agentes antibacterianos Etodolac sinergia de fármacos relación estructura-actividad azoles

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