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Muerte celular programada de queratinocitos: un motor activo en la psoriasis
Tianyi Yuwen1, Jingyu Tian1, Yujie Chen1
1Jiangsu Provincial Key Laboratory of Dermatology, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, 12 Jiangwangmiao St., Nanjing, 210042, People's Republic of China.
Apoptosis : an international journal on programmed cell death
|January 10, 2026
Resumen
La psoriasis implica motores activos de las células de la piel, no solo víctimas pasivas. La comprensión de la muerte celular programada (PCD) en estas células ofrece nuevos objetivos terapéuticos para este trastorno crónico de la piel inflamatoria.
Área de la Ciencia:
- Dermatología
- Inmunología
- Biología Celular
Sus antecedentes:
- La psoriasis es una enfermedad inflamatoria crónica prevalente de la piel que afecta a individuos y a la sociedad.
- Implica hiperplasia epidérmica e infiltración de células inmunes, y los queratinocitos impulsan activamente la inflamación.
- La muerte celular programada (PCD) de los queratinocitos es un factor clave que interactúa con las células inmunes y las señales inflamatorias.
Objetivo del estudio:
- Revisar las principales vías de muerte celular programada (PCD) en queratinocitos relevantes para la patogénesis de la psoriasis.
- Examinar los roles de la apoptosis, necroptosis, ferroptosis y piroptosis en la piel psoriásica.
- Resumir las estrategias terapéuticas dirigidas a la muerte celular de queratinocitos en la psoriasis.
Principales métodos:
- Revisión de la literatura de las vías de muerte celular programada (PCD) en queratinocitos.
- Análisis de la interacción entre la PCD de queratinocitos y el microambiente psoriásico.
- Resumen de los avances terapéuticos actuales y emergentes que modulan la muerte celular de queratinocitos.
Principales resultados:
- Los queratinocitos son impulsores activos de la psoriasis, no víctimas pasivas.
- Se implican múltiples vías de PCD (apoptosis, necroptosis, ferroptosis, piroptosis) en la psoriasis.
- Las moléculas relacionadas con la PCD en los queratinocitos muestran potencial como biomarcadores diagnósticos y objetivos terapéuticos.
Conclusiones:
- La muerte celular programada (PCD) en queratinocitos es central en la patogénesis de la psoriasis.
- Dirigirse a las vías de PCD de queratinocitos ofrece vías prometedoras para nuevos tratamientos de la psoriasis.
- La comprensión de estas vías puede informar el desarrollo de nuevas estrategias diagnósticas y terapéuticas para la psoriasis.
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