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Alcaloides de acónito de Gymnaconitum gymnandrum

Guo-Li Li¹, Lei Zhang¹, Hong-Ying Yang¹

¹Research Institute, School of Biological and Pharmaceutical Engineering, Lanzhou Jiaotong University, Lanzhou, P. R. China.

Chemistry & biodiversity

|January 10, 2026

Abstract:

Two previously uncharacterized C₁₉-diterpenoid alkaloids (1 and 2) and seven known ones (3-9) were isolated from Gymnaconitum gymnandrum. Their structures were elucidated based on spectroscopic data, including one- and two-dimensional nuclear magnetic resonance, infrared, high-resolution electrospray ionization mass spectrometry, and single-crystal X-ray diffraction analysis. These compounds were tested for their insecticidal activity and anti-chlamydial activity. The results show that compound 1 has the most insecticidal activity, with a median lethal concentration value of 0.73 ± 0.08 mg/mL; compound 3 exhibits an anti-chlamydia effect at a concentration of 100 µM.

Palabras clave:

C19-diterpenoides Gymnaconitum gymnaconitum actividad anticlamidial actividad insecticida

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