Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

RNA Polymerase II Accessory Proteins02:36

RNA Polymerase II Accessory Proteins

10.7K
Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
10.7K
RNA Polymerase II Accessory Proteins02:36

RNA Polymerase II Accessory Proteins

3.8K
3.8K
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

8.4K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
8.4K
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

3.0K
3.0K
Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

7.1K
Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
7.1K
Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

2.4K
2.4K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Spatiotemporal control of myoblast identity drives muscle diversity in the <i>Drosophila</i> leg.

Science advances·2026
Same author

Spatial-scERA: a method for reconstructing spatial single-cell enhancer activity in multicellular organisms.

Nucleic acids research·2025
Same author

Dual topologies of myotomal collagen XV and Tenascin C act in concert to guide and shape developing motor axons.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

Chromatin gene-gene loops support the cross-regulation of genes with related function.

Molecular cell·2023
Same author

Enhancer-promoter interactions can form independently of genomic distance and be functional across TAD boundaries.

Nucleic acids research·2023
Same author

Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells.

Nature communications·2021
Same journal

Decoding bipotency: a transient regulatory state bridging totipotency and lineage commitment.

Current opinion in genetics & development·2026
Same journal

Functional immunogenomics and deep clinical phenotyping to resolve the challenges of heterogeneity in mental disorders.

Current opinion in genetics & development·2026
Same journal

Temporal trajectories underlying adult neuronal diversity.

Current opinion in genetics & development·2026
Same journal

Transcription regulation of cell fate plasticity - from embryonic development to tissue regeneration.

Current opinion in genetics & development·2026
Same journal

Shared molecular and cellular programs during regeneration of glandular epithelia.

Current opinion in genetics & development·2026
Same journal

Lineage tracing in human cortical development.

Current opinion in genetics & development·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Jan 13, 2026

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

3.0K

Cooperatividad entre elementos reguladores como modulador de la función del potenciador

Deevitha Balasubramanian1, Margarita Masoura1, Yad Ghavi-Helm1

  • 1Institut de Génomique Fonctionnelle de Lyon, UMR5242, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard-Lyon 1, 46 allée d'Italie, F-69364 Lyon, France.

Current opinion in genetics & development
|January 10, 2026
PubMed
Resumen
Este resumen es generado por máquina.

La regulación génica involucra promotores y potenciadores, pero nuevas secuencias como los elementos proximales al promotor ajustan este proceso. Estos elementos funcionan a lo largo de un continuo regulador, esencial para comprender genomas complejos.

Palabras clave:
elementos reguladorespotenciadorespromotoreselementos proximales al promotorcontinuo reguladorgenomas complejosregulación génicaexpresión génicabiología moleculargenéticagenómica

Más Videos Relacionados

Optimized Quantitative Assessment of Enhancer RNA Stability in Mouse Embryonic Stem Cells
03:34

Optimized Quantitative Assessment of Enhancer RNA Stability in Mouse Embryonic Stem Cells

Published on: November 21, 2025

216
Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation
09:07

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation

Published on: June 21, 2016

8.6K

Videos de Experimentos Relacionados

Last Updated: Jan 13, 2026

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

3.0K
Optimized Quantitative Assessment of Enhancer RNA Stability in Mouse Embryonic Stem Cells
03:34

Optimized Quantitative Assessment of Enhancer RNA Stability in Mouse Embryonic Stem Cells

Published on: November 21, 2025

216
Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation
09:07

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation

Published on: June 21, 2016

8.6K

Área de la Ciencia:

  • Biología Molecular
  • Genética
  • Genómica

Sus antecedentes:

  • La transcripción génica está regulada clásicamente por promotores y potenciadores.
  • Descubrimientos recientes revelan secuencias reguladoras adicionales que ajustan la expresión génica.

Objetivo del estudio:

  • Revisar las secuencias reguladoras descritas recientemente: elementos proximales al promotor y moduladores similares a potenciadores.
  • Analizar sus funciones, mecanismos e impacto en las definiciones actuales de elementos reguladores génicos.

Principales métodos:

  • Revisión de literatura de elementos proximales al promotor y moduladores similares a potenciadores.
  • Análisis de ejemplos representativos y mecanismos de acción propuestos.

Principales resultados:

  • Los elementos proximales al promotor y los moduladores similares a potenciadores influyen significativamente en la función del potenciador y en la producción transcripcional.
  • Estos elementos desafían las clasificaciones discretas, lo que sugiere un continuo regulador.

Conclusiones:

  • Los elementos reguladores génicos pueden no encajar en clases discretas, sino que existen en un continuo.
  • Comprender este continuo es crucial para descifrar la regulación génica en genomas complejos.