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Updated: Jan 13, 2026
Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
Published on: January 13, 2023
Marcos moleculares de base de manganeso aumentan la inmunoterapia postoperatoria de ultrasonido enfocado de alta
Xinchang Huang1, Xirui Luo1, Tong Su2
1Department of Radiology, Women and Children's Hospital of Chongqing Medical University, 400016 Chongqing, PR China; State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, 400016 Chongqing, PR China.
Abstract:
Limited antigen presentation renders high-intensity focused ultrasound (HIFU)-triggered immune response insufficient to improve prognosis. Herein, manganese-based metal-organic frameworks (termed AMS MOFs) were designed to co-deliver hypoxia-activated prodrug banoxantrone (AQ4N) and stimulator of interferon genes (STING) agonist SR-717, for enhancing antigen presentation-related postoperative immunotherapy. Under hypoxic microenvironment after HIFU surgery, the released AQ4N initiated immunogenic cell death causing the release of danger-associated molecular patterns. Simultaneously, SR-717 activated STING pathway and together with Mn2+-promoted the binding affinity of cGAMP-STING, finally eliciting robust type I interferon response. The synergism of these processes consequently promoted immune responses relevant to tumor antigen presentation and inhibited breast tumor recurrence and metastasis. This study presents a strategy for improving the overall prognosis of all surgery including HIFU.
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