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Updated: Jan 13, 2026
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Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
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La PARsilación mediada por Tankyrase-1 dirige el cambio de pareja de TFEB para regular la expresión génica selectiva
Gahyeon Song1, Chanhyeok Park2, Eek-Hoon Jho1
1Department of Life Science, University of Seoul, Seoul, Republic of Korea.
Molecules and cells
|January 10, 2026
Resumen
La señalización de Wnt reprograma el factor de transcripción TFEB
Sus antecedentes:
- La señalización Wnt/β-catenina regula la expresión génica en el desarrollo y el cáncer.
- TFEB, un regulador maestro de la biogénesis lisosomal y la autofagia, actúa como un correceptor inducible por Wnt para algunos genes diana de Wnt.
- El mecanismo de la participación selectiva de TFEB en la señalización de Wnt no estaba claro previamente.
Conclusiones:
- Se descubrió un nuevo mecanismo de cambio de pareja dependiente de PARsilación para TFEB.
- La señalización de Wnt reprograma la producción transcripcional de TFEB alterando su preferencia de unión de homodímeros a complejos TCF-1/LEF-1.
- Este mecanismo pone de relieve una nueva capa de regulación en el control transcripcional mediado por Wnt.
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