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Updated: Jan 13, 2026

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Activación secuencial de la ARN polimerasa II impulsa la hematopoyesis humana

Derek H Janssens1, Christine A Codomo2, Dominik J Otto3

  • 1Department of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.

Cell reports
|January 11, 2026
PubMed
Resumen

Las células madre adultas utilizan la ARN polimerasa II (Pol II) en pausa para responder rápidamente a las señales inflamatorias. Este estudio revela una cascada temporal de activación de Pol II que guía el desarrollo de las células inmunitarias y las respuestas al estrés.

Palabras clave:
biología molecularinvestigación de células madreCUT&Tagrespuesta a G-CSFARN polimerasa IIcélulas madre hematopoyéticasmemoria inflamatoriadeterminación del linajerepresión de PolycombsciCUT&Tag2in1genómica unicelularpausa transcripcional

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