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Updated: Jan 13, 2026

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Prueba de las defensas de la naturaleza: Inducción de cáncer en la rata topo desnuda

Amy M Boddy¹, Lisa M Abegglen^2,3

¹Integrative Anthropological Sciences, University of California, Santa Barbara, Santa Barbara, California.

Cancer discovery

|January 12, 2026

Abstract:

Although mice develop lung cancer from a single Eml4-Alk driver fusion, Shepard, Lester, and colleagues show that naked mole rats require three simultaneous oncogenic events: Eml4-Alk, Tp53 loss, and Rb1 loss, achieving only 30% tumor penetrance. This inducible cancer model in naked mole rats offers a unique platform for uncovering mechanisms of cancer resistance and modeling rare pleomorphic lung carcinomas. See related article by Shepard et al., p. 35.

Palabras clave:

rata topo desnuda cáncer de pulmón resistencia al cáncer modelos de cáncer oncogenes supresores de tumores

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