Video Experimental Relacionado

Updated: Jan 13, 2026

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

Published on: March 21, 2020

La relación neutrófilo-linfocito predice la progresión de la ansiedad en la enfermedad de Parkinson

Dehao Yang¹, Zijia Liu², Shenyi Lin³

¹Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China.

Movement disorders clinical practice

|January 12, 2026

Abstracto

Background:

Anxiety progression in Parkinson's disease (PD) and its link to peripheral inflammation remain unclear.

Objective:

This study aimed to determine whether lymphocyte-related inflammatory markers can predict the longitudinal progression of anxiety symptoms in patients with PD.

Methods:

This study utilized a large public database to evaluate 13 inflammatory markers associated with lymphocytes. Linear regression and mixed-effects models were employed to assess associations between the inflammatory indicators and anxiety symptoms.

Results:

Elevated baseline neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) were associated with higher levels of both state and trait anxiety (P < 0.05). An increase in the NLR is indicative of the deterioration of trait anxiety (estimate = 0.455, P = 0.030), especially in late-onset PD (LOPD) patients and males.

Conclusions:

The NLR is a potential biomarker for the progression of anxiety in PD patients, indicating that neuroinflammation is related to anxiety.

Palabras clave:

Enfermedad de Parkinson ansiedad inflamación relación neutrófilo-linfocito

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