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QuickProt: Una herramienta rápida y precisa de anotación de proteínas basada en homología para organismos no modelo
Guisen Chen1, Hehe Du1, Zhenjie Cao1
1Sanya Institute of Breeding and Multiplication, School of Marine Biology and Fisheries, Collaborative Innovation Center of Marine Science and Technology, Hainan University, Haikou, Hainan, China.
Molecular ecology resources
|January 12, 2026
Resumen
QuickProt es una nueva herramienta de anotación de proteínas basada en homología que acelera significativamente el análisis genómico para especies sin datos de transcriptoma. Proporciona modelos de genes precisos, lo que ayuda a la genómica comparativa y a los estudios evolutivos.
Área de la Ciencia:
- Genómica; Bioinformática; Biología Evolutiva
Sus antecedentes:
- La secuenciación del genoma está avanzando rápidamente, pero las herramientas de anotación eficientes, particularmente para especies que carecen de datos de transcriptoma, están rezagadas.
- Los métodos de anotación existentes pueden ser computacionalmente intensivos y pueden no escalar de manera efectiva para estudios genómicos comparativos a gran escala.
Objetivo del estudio:
- Presentar QuickProt, una herramienta novedosa, rápida, precisa y fácil de usar para la anotación de proteínas basada en homología.
- Proporcionar una solución rentable para generar modelos de genes no redundantes para especies que carecen de datos de transcriptoma.
- Facilitar análisis genómicos comparativos a gran escala e inferencia evolutiva.
Principales métodos:
- QuickProt alinea proteínas homólogas de especies estrechamente relacionadas para construir modelos de genes no redundantes.
- Se realizó una evaluación comparativa frente a herramientas establecidas (BRAKER2, GALBA) en genomas de referencia.
- La herramienta se aplicó a diversos genomas, incluido un teleósteo no modelo, Xenopus tetraploide y plantas de Rutaceae.
Principales resultados:
- QuickProt demostró alta especificidad y un tiempo de ejecución significativamente mejorado en comparación con BRAKER2 y GALBA, manteniendo al mismo tiempo una precisión de anotación competitiva.
- La herramienta apoyó con éxito la reconstrucción filogenética robusta, la identificación de ortólogos conservados y la detección de genes/vías funcionales en diversos niveles de ploidía.
- Los hallazgos específicos incluyen un evento potencial de transferencia horizontal de genes y módulos conservados en la biosíntesis de aceites volátiles de cítricos.
Conclusiones:
- QuickProt ofrece una plataforma escalable y computacionalmente eficiente para la anotación genómica y la inferencia evolutiva.
- La herramienta acelera la genómica comparativa y la exploración funcional en diversos taxones.
- QuickProt es valioso para los investigadores que se enfrentan al creciente volumen de genomas secuenciados, especialmente aquellos que carecen de datos de transcriptoma.
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