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Un método mejorado de medición de la tortuosidad que combina la curvatura, la búsqueda en anchura y la distancia
Nur Asyiqin Amir Hamzah1,2, Wan Mimi Diyana Wan Zaki2, Aziah Ali3
1Centre of Advanced Analytics, Faculty of Engineering and Technology, Multimedia University, Jalan Ayer Keroh Lama, Melaka, Malaysia.
PeerJ
|January 12, 2026
Resumen
La tortuosidad vascular retiniana difiere entre arterias y venas, siendo las venas más tortuosas en ojos sanos. El campo de visión de la imagen impacta significativamente las mediciones, lo que requiere estandarización para la precisión diagnóstica.
Área de la Ciencia:
- Oftalmología e Imagen Médica; Ingeniería Biomédica; Análisis Cuantitativo de Imágenes
Sus antecedentes:
- La tortuosidad vascular retiniana es un biomarcador clave para enfermedades sistémicas y oculares.; La evaluación cuantitativa, especialmente la diferenciación entre arterias y venas, está poco explorada.; Se necesitan métodos estandarizados para un análisis fiable de la tortuosidad.
Objetivo del estudio:
- Evaluar cuantitativamente la tortuosidad vascular retiniana en ojos sanos y enfermos.; Diferenciar la tortuosidad entre arterias y venas en todos los conjuntos de datos.; Investigar el impacto de parámetros de imagen como el campo de visión (FOV) en la tortuosidad.
Principales métodos:
- Se utilizaron tres conjuntos de datos públicos (DRIVE, HRF, LES-AV) para el análisis.; Se aplicó un flujo de trabajo que incluye segmentación de vasos, separación de arterias y venas, esqueletización y trazado basado en el disco óptico.; Se empleó la búsqueda en anchura (BFS) para un trazado robusto de la ruta del vaso y métricas basadas en la curvatura.
Principales resultados:
- Las venas mostraron una tortuosidad significativamente mayor que las arterias en ojos sanos en todos los conjuntos de datos.; Los casos de retinopatía diabética exhibieron diferencias amplificadas en la tortuosidad entre arterias y venas.; Los conjuntos de datos con un FOV más amplio (DRIVE, HRF) reportaron valores de tortuosidad más altos que los de FOV más estrecho (LES-AV).
Conclusiones:
- La tortuosidad vascular retiniana es un biomarcador robusto y específico de los vasos.; Las mediciones se ven influenciadas por parámetros de imagen, en particular el FOV y la orientación del disco óptico.; La estandarización de los parámetros de imagen es crucial para las aplicaciones de diagnóstico y las comparaciones entre estudios.
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