Video Experimental Relacionado

Updated: Jan 13, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Roles duales de las proteínas del reloj circadiano en el desarrollo y la homeostasis adulta

Matthew Choi^1,2, Stacy Liang^1,2, Juan R Alvarez-Dominguez^1,2

¹Chronobiology and Sleep Institute, Institute for Diabetes, Obesity and Metabolism, and Institute for Regenerative Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA USA.

Npj biological timing and sleep

|January 12, 2026

Abstract:

Circadian clocks coordinate physiology with daily cycles. Loss of circadian components disrupts bodily functions, but the phenotypes differ when disruption occurs during development or adulthood. Here, we compare effects of manipulating mammalian clock proteins across life stages, reviewing roles of BMAL1 and REV-ERBα/β in embryogenesis-skeletal formation, metabolic programming, cardiovascular development-and adulthood-tissue integrity, metabolic adaptation, neuroprotection. We further discuss mechanisms for dual involvement, and implications for stage-specific therapies.

Palabras clave:

Biología celular Biología del desarrollo

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