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Enfermedad de Castleman con manifestación sistémica: reporte de un caso
Ahlam Hmimsa1, Nabil Touihem1, Hicham Attifi1
1Service d'Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale, Hôpital Militaire Moulay Ismail, Meknès, Maroc.
The Pan African medical journal
|January 12, 2026
Resumen
La enfermedad de Castleman es un trastorno linfoproliferativo raro. Este caso destaca el diagnóstico de la enfermedad de Castleman multicéntrica en un paciente con polipadenopatía inexplicable y síntomas sistémicos.
Área de la Ciencia:
- Hematología; Oncología; Inmunología
Sus antecedentes:
- La enfermedad de Castleman es un trastorno linfoproliferativo raro.
- Se presenta con linfadenopatía y síntomas sistémicos, con dos formas: unicentrica y multicéntrica.
- La enfermedad de Castleman multicéntrica implica afectación difusa de los ganglios linfáticos y producción excesiva de interleucina-6 (IL-6).
Objetivo del estudio:
- Reportar un caso de enfermedad de Castleman multicéntrica.
- Enfatizar la importancia de considerar la enfermedad de Castleman en la polipadenopatía inexplicable con manifestaciones sistémicas.
Principales métodos:
- Reporte de caso de un paciente de 65 años con polipadenopatía y fenómeno de Raynaud.
- El estudio diagnóstico incluyó imágenes (linfadenopatías, hepatoesplenomegalia), cervicotomía exploratoria, examen histopatológico y análisis inmunohistoquímico.
Principales resultados:
- La histopatología y la inmunohistoquímica confirmaron la enfermedad de Castleman multicéntrica.
- El paciente presentó polipadenopatía, fenómeno de Raynaud y hepatoesplenomegalia.
Conclusiones:
- La enfermedad de Castleman debe considerarse en el diagnóstico diferencial de las polipadenopatías inexplicables.
- Las manifestaciones sistémicas atípicas justifican una investigación exhaustiva de la enfermedad de Castleman.
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