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Updated: Jan 13, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Terapia de Resincronización Cardíaca: Reconsiderando su Esencia como Tratamiento para la Disincronía Eléctrica en la
Michio Ogano1, Yu-Ki Iwasaki2, Jun Tanabe1
1Department of Cardiovascular Medicine Shizuoka Medical Center Shimizu Japan.
Abstract:
Cardiac resynchronization therapy (CRT) essentially targets electrical dyssynchrony, one of the key drivers in heart failure (HF). Its efficacy depends on both the quality (QRS morphology) and quantity (QRS duration) of dyssynchrony, requiring individualized patient selection. While drug therapy for HF has a limited effect on this substrate, early implantation of CRT can prevent irreversible remodeling and facilitate optimization of medical therapy. CRT should be recognized as an essential component within a comprehensive strategy for HF management in patients with appropriate indications.
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