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La deficiencia de 25-hidroxivitamina D eleva el riesgo de incidencia y mortalidad de EPOC: un estudio de cohorte
Ying Zhu1,2, Shengjie Zhao3, Chen Zhu4
1Senior Department of Pulmonary and Critical Care Medicine, the Eighth Medical Center of Chinese PLA General Hospital, Beijing, China.
Background:
The association between 25(OH)D levels and chronic obstructive pulmonary disease (COPD) remains unclear. The study aims to investigate the association between 25(OH)D concentrations and the incidence and survival of COPD in the UK Biobank cohort.
Methods:
We conducted a cross-sectional analysis using UK Biobank data from 328,855 participants with complete 25(OH)D records. This analysis examined the association between 25(OH)D levels and COPD prevalence via logistic regression. Additionally, we prospectively followed a cohort of 327,871 individuals without baseline COPD. We assessed the risk of incident COPD and survival outcomes in this cohort using multivariable-adjusted Cox proportional hazards models. Kaplan-Meier estimates were used to generate survival curves.
Results:
The prevalence of COPD was significantly higher in individuals with 25(OH)D deficiency compared to those with normal level, as evidenced by adjusted OR(95% CI) of 1.266(1.206-1.330) for COPD. During the median follow-up period of 15 years (IQR: 14-16 years), the overall COPD incidence was 262.3 per 10,000 person years, with higher rates among those with 25(OH)D deficiency (345.2 per 10,000 person years) compared to normal levels (232.6 per 10,000 person years) (p<0.001).In fully adjusted models, 25(OH)D deficiency was significantly associated with increased COPD incidence[HR 1.874, 95% CI 1.659 to 2.117] and mortality [HR 1.598, 95% CI 1.406-1.816]. Subgroup analyses revealed stronger associations with COPD incidence among men, current smokers, and individuals not taking vitamin D supplements, as well as an increased COPD mortality risk among patients with depression (p for interaction <0.05).
Conclusions:
Our study suggests that 25(OH)D deficiency is associated with COPD incidence and survival, providing a basis for preventive strategies and interventions.
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