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Updated: Jun 15, 2026

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PTPA fosfatasa vía de señalización en el silenciamiento del genoma del gen de la hemoglobina fetal optimizado por

Elizabeth A Traxler1, Quynn Hotan2, Yue Shao3

  • 1University of Pennsylvania Perelman School of Medicine, United States.

Blood
|January 12, 2026
PubMed
Resumen

Este estudio utilizó el cribado CRISPR para identificar nuevos reguladores de la expresión génica de la globina fetal (HBG1/2). Se descubrió que PTPA silencia la globina fetal regulando BCL11A, lo que ofrece una diana terapéutica potencial para las hemoglobinopatías.

Palabras clave:
PTPAhemoglobina fetalsilenciamiento génicoCRISPR-Cas12ahematologíagenéticabiología molecularhemoglobinopatíasBCL11A

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