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Microcápsula activada por enzimas similar a un fusible para encapsular probióticos: tratamiento de la colitis

Qikun Cheng¹, Mingzhi Xie², Ting Wu³

¹Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, China; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Provincial Engineering and Technological Research Center for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.

International journal of pharmaceutics

|January 12, 2026

Abstract:

Ulcerative colitis is a chronic inflammatory disease, and probiotics have been used for its treatment owing to their efficiency and safety. However, the poor ability of bare probiotics to colonize the colon impairs their anti-inflammatory effects. In our study, an enzyme-triggered fuse-like microcapsule (AP_2.0) developed in our previous work was used to encapsulate the probiotic Bifidobacterium Longum subsp. Infantis GIM 1.207 (Bl.infantis) for the treatment of ulcerative colitis. Mice were administered AP_2.0@Bl.infantis via gavage every other day for seven days. The results demonstrated that the body weight, visceral sections, disease activity index, blood biochemical parameters, cytokines, and blood cells of the AP_2.0@Bl.infantis group suggested that the inflammatory response tended to be relieved. The results of 16S rRNA gene sequencing revealed that AP_2.0@Bl.infantis could enhance the abundance of Odoribacter, Marinifilaceae, Ruminococcaceae, and Ruminiclostridium_6 spp., which belong to the normal intestinal microflora, to upregulate Bacteroidetes and Firmicutes. In conclusion, compared with the anti-inflammatory drug Mesalazine, AP_2.0@Bl.infantis can more effectively positively regulate the intestinal flora and alleviate inflammation.

Palabras clave:

Dirigido al colon Administración oral Probióticos Colitis ulcerosa

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