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Consideraciones sobre inmunoterapia para neuropatías periféricas distales predominantemente sensoriales y de fibras

Anne Louise Oaklander¹

¹Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States; Department of Pathology (Neuropathology), Massachusetts General Hospital, Boston, MA, United States.

Handbook of clinical neurology

|January 12, 2026

Resumen

Las polineuropatías sensoriales distales (DSP) se tratan cada vez más con inmunoterapia, especialmente cuando se sospechan causas autoinmunes en casos idiopáticos. La evidencia sugiere que la inmunoterapia beneficia a algunos pacientes, guiando las decisiones de tratamiento.

Conclusiones:

La inmunoterapia se considera cada vez más para las iiDSP disinmunes, especialmente en pacientes jóvenes con un impacto significativo en la vida.
Las decisiones de tratamiento requieren una cuidadosa consideración de los riesgos, costos y datos limitados de ensayos controlados.
El desarrollo de recomendaciones de consenso para la selección de inmunoterapia en iiDSP es crucial para pacientes, médicos y pagadores.

Palabras clave:

Autoanticuerpos Corticosteroides Trastornos inmunitarios Inmunoterapia Terapia de inmunoglobulina intravenosa Neuropatía periférica Plasmaféresis Polineuropatía Neuropatía de fibras pequeñas

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