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Papel de la respuesta del complemento en las autoinmunidades neurológicas: Por qué es necesario dirigir la activación

Marinos C Dalakas¹, Peter J Späth²

¹Department of Neurology, Thomas Jefferson University, Philadelphia, PA, United States; Neuroimmunology Unit, Department of Pathophysiology, National and Kapodistrian University of Athens Medical School, Athens, Greece.

Handbook of clinical neurology

|January 12, 2026

Resumen

El sistema del complemento protege el cuerpo pero puede causar enfermedades autoinmunes. La focalización del complemento con nuevas terapias muestra resultados prometedores para el tratamiento de trastornos neurológicos autoinmunes.

Conclusiones:

Las inmunoterapias dirigidas al complemento, incluidos los nuevos biológicos, son eficaces para suprimir las autoinmunidades neurológicas.
Los agentes anticomplemento emergentes muestran potencial terapéutico para las afecciones neurológicas autoinmunes resistentes a los tratamientos actuales.
Se necesitan más investigaciones y ensayos clínicos para optimizar las terapias basadas en el complemento.

Palabras clave:

Terapias anticomplemento C3 y C5 y enfermedades neurológicas autoinmunes CD59 Vías clásica, alternativa y de lectina Activación del complemento y autoinmunidad del sistema nervioso Factores de activación del complemento Terapias dirigidas al complemento y enfermedades neurológicas autoinmunes Complejo de ataque membranolítico y lesión nerviosa o muscular Terapias dirigidas al complejo C1qC1r2C1s2 y C2 en neurología

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