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Updated: Jan 14, 2026

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Pequeños moduladores de empalme de moléculas que alteran la homeostasis de O-GlcNAc

Steven S Cheng1, Alison C Mody1, Amedeo Vetere2

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.

Nature communications
|January 12, 2026
PubMed
Resumen

Las pantallas de reutilización de fármacos identificaron inhibidores de quinasas que alteran la homeostasis de O-GlcNAc al modular el empalme. Estos compuestos regulan a la baja la O-GlcNAc transferasa (OGT) y la O-GlcNAcasa (OGA) independientemente de sus dianas conocidas.

Palabras clave:
inhibidores de quinasasmodulación del empalmehomeostasis de O-GlcNAcreutilización de fármacosOGTOGA

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