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Updated: Jun 21, 2026

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Bioimpresión de hidrogel sensible a colagenasa para la liberación controlada de inmunoterapia con virus del mosaico

Zhongchao Zhao¹, Yi Xiang², Zhuohong Wu³

¹University of California San Diego, 9500 Gilman Dr., SME203C MC0448, La Jolla, La Jolla, California, 92093-0001, UNITED STATES.

|January 13, 2026

Abstract:

In this work, we developed a collagenase-responsive hydrogel system to covalently load cancer immunotherapy candidate cowpea mosaic virus (CPMV) using 3D Digital Light Processing (DLP) bioprinting technology. CPMV was functionalized with norbornene groups (CPMV-NB), which was then bioprinted into hydrogels with 8-arm polyethylene glycol (PEG) norbornene and a collagenase-cleavable peptide via photoinduced thiol-ene click chemistry. This strategy enabled stable retention of CPMV-NB within the hydrogels and achieved controlled release of CPMV-NB triggered by collagenase. Furthermore, released CPMV-NB retained its immunogenicity to stimulate immune cells.

Palabras clave:

bioimpresión liberación controlada hidrogel inmunoterapia

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