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Sistemas de administración de ARN dirigidos a los pulmones: estrategias y aplicaciones terapéuticas

Shenrui Xu^1,2,3, Min Li², Tingting Wang⁴

¹Key Laboratory of Biomacromolecules, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100091, China.

Journal of nanobiotechnology

|January 13, 2026

Resumen

Las terapias de ARN ofrecen promesas para enfermedades pulmonares como el asma y la EPOC. Esta revisión detalla cómo el diseño del sistema de administración afecta la focalización pulmonar y la eficacia, ofreciendo una hoja de ruta para la traducción clínica.

Sus antecedentes:

Las enfermedades pulmonares (asma, cáncer de pulmón, EPOC, fibrosis) causan importantes cargas de salud a nivel mundial.
Las terapias de ARN muestran promesas para la modulación de enfermedades a nivel molecular.
La administración de ARN eficiente y específica para los pulmones es un obstáculo importante para la aplicación clínica.

Conclusiones:

La comprensión de las relaciones estructura-función es clave para diseñar sistemas eficaces de administración de ARN pulmonar.
Abordar la estabilidad de la formulación, la compatibilidad inmunológica y la fabricación escalable es crucial para el éxito clínico.
Esta revisión proporciona un marco para avanzar las terapias de ARN para enfermedades pulmonares desde el laboratorio hasta la clínica.

Palabras clave:

Exosomas Nanopartículas lipídicas Administración dirigida a los pulmones Nanotransportadores Terapias de ARN Nanomedicina traslacional

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