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Señal de localización nuclear en Leishmania spp.: Implicaciones para la fisiología del parásito y la secuestro del

Lara da Mata Aredes Riguetti¹, Carlos Roberto Alves¹, Franklin Souza da Silva²

¹Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Biologia Molecular e Doenças Endêmicas, Avenida Brasil 4365, CEP 21040-900, Manguinhos, Rio de Janeiro, RJ, Brazil.

|January 14, 2026

Resumen

Las señales de localización nuclear (NLS) son cruciales para el transporte de proteínas en eucariotas. En los parásitos Leishmania, las NLS en las proteasas pueden dirigirse a los núcleos de las células huésped, lo que ayuda a la supervivencia del parásito y ofrece posibles objetivos terapéuticos para la leishmaniasis.

Área de la Ciencia:

Biología Celular
Parasitología
Biología Molecular

Sus antecedentes:

El transporte de proteínas al núcleo es vital para la función celular eucariota.
Las señales de localización nuclear (NLS) median este transporte a través de proteínas adaptadoras.
El transporte mediado por NLS es esencial para el parásito Leishmania.

Objetivo del estudio:

Revisar la clasificación y diversidad de las NLS.
Explorar el papel de las NLS en la fisiología de Leishmania.
Investigar el potencial de las NLS en las interacciones parásito-huésped y las estrategias terapéuticas.

Principales métodos:

Revisión de la literatura sobre la clasificación y función de las NLS.
Análisis de la presencia de NLS en proteínas de Leishmania, incluidas las proteasas.
Examen de la interacción de las metaloproteasas GP63 con factores nucleares del huésped.

Principales resultados:

Las NLS son diversas y esenciales para Leishmania.
Las proteasas de Leishmania poseen NLS, lo que sugiere roles duales.
Las proteasas GP63 interactúan con componentes nucleares del huésped, modulando la transcripción y promoviendo la supervivencia.

Conclusiones:

Leishmania utiliza NLS en proteasas como una sofisticada estrategia de supervivencia.
Este mecanismo implica la modulación de la dinámica nuclear del huésped.
Se necesita más investigación para la confirmación experimental y el desarrollo terapéutico contra la leishmaniasis.

Palabras clave:

Interacción huésped-patógeno Leishmania spp.Señal de localización nuclear Transporte nucleocitoplasmático Proteasas Factores de virulencia

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