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Updated: Jan 17, 2026

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Revolución en el desarrollo de ELISA: El impacto transformador de la automatización en los ensayos de potencia de

Xiaoran Xin¹, Douglas Pung¹, Amy Hsu¹

¹Analytical Research & Development, Merck & Co., Inc., Rahway, NJ, USA.

Journal of pharmaceutical and biomedical analysis

|January 14, 2026

Abstract:

Enzyme-linked immunosorbent assays (ELISA) are a fundamental technique for determining the potency of monoclonal antibodies (mAbs), yet the traditional ELISA development process is often time-consuming and labor-intensive. In this study, we explored how automation and miniaturization in a 384-well format can revolutionize ELISA development, significantly enhancing throughput and accuracy. By employing automated liquid dispensing technology, we streamlined the optimization of assay parameters, leading to faster and more reliable potency measurements. Our findings not only demonstrate the feasibility of this innovative approach but also highlight its potential to transform the landscape of analytical assays in biopharmaceutical development.

Palabras clave:

Anticuerpo Automatización ELISA Potencia

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