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Efectos protectores de los péptidos de polisacáridos de Ganoderma lucidum contra la toxicidad inducida por cisplatino
Zumin Hou1, Weiling Ji2, Shangpeng Yang1
1Key laboratory of molecular pharmacology and translational research, School of Pharmacy, Shandong Second Medical University, Weifang 261053, Shandong, China.
Journal of ethnopharmacology
|January 15, 2026
Resumen
Los péptidos de Ganoderma lucidum (GL-PP y GL-PP2) protegen contra la toxicidad del cisplatino en múltiples órganos. GL-PP2 demuestra una eficacia superior al reducir la inflamación, el estrés oxidativo y la apoptosis a través de vías de señalización específicas.
Área de la Ciencia:
- Farmacología y Toxicología
- Investigación de Productos Naturales
- Biología Celular y Molecular
Sus antecedentes:
- Ganoderma lucidum (G. lucidum) es una medicina tradicional china con un historial de uso para la vitalidad y el apoyo de órganos.
- Sus extractos son conocidos por sus propiedades inmunomoduladoras y antioxidantes, lo que los hace de interés para la protección de órganos.
- G. lucidum se ha utilizado tradicionalmente para controlar la inflamación crónica, la fatiga y las lesiones orgánicas inducidas por toxinas.
Objetivo del estudio:
- Investigar los efectos protectores del péptido de polisacárido de G. lucidum (GL-PP) y el péptido de polisacárido de G. lucidum 2 (GL-PP2) contra la toxicidad multiorgánica inducida por cisplatino (CDDP).
- Explorar los mecanismos de acción subyacentes de GL-PP y GL-PP2 para mitigar la toxicidad inducida por CDDP.
Principales métodos:
- Se emplearon modelos in vivo e in vitro para evaluar la protección de órganos.
- Se evaluaron los índices bioquímicos clave, los cambios histológicos, el estrés oxidativo, la inflamación, la fibrosis y la apoptosis.
- Se utilizó la farmacología de redes y el Western blot para dilucidar los mecanismos moleculares.
Principales resultados:
- GL-PP y GL-PP2 mejoraron la función cardíaca, hepática y renal, reduciendo el daño y la fibrosis causados por CDDP.
- GL-PP2 (200 mg/kg) mostró efectos antiinflamatorios y antioxidantes significativos al activar la vía Akt/GSK-3β/Nrf2.
- Reguló proteínas clave relacionadas con la apoptosis, incluyendo BCL-2, BAX y caspase-3 escindida.
Conclusiones:
- GL-PP y GL-PP2 proporcionan protección multiorgánica contra la toxicidad de CDDP.
- La protección se media principalmente por la activación de la vía de señalización Akt/GSK-3β/Nrf2.
- GL-PP2 demostró una eficacia protectora superior en comparación con GL-PP.
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