Video Experimental Relacionado

Updated: Jan 18, 2026

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles

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Published on: July 6, 2012

Estudio cinético multidimensional de la polimerización por apertura de anillo (ROP) de l-lactida organocatalizada a

Bo Zhang¹, Tanja Junkers¹

¹Polymer Reaction Design Group, School of Chemistry, Monash University 17 Rainforest Walk Clayton VIC 3800 Australia tanja.junkers@monash.edu.

Chemical science

|January 16, 2026

Abstract:

Ring-opening polymerization (ROP) of l-lactide catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) was efficiently screened via a programmable high-throughput robotic flow platform with very high accuracy (absolute error <5%). With a very significant amount of data being generated, a rate law describing living ROP initiated by TBD that includes a first-order dependency in l-lactide, a first-order dependency in TBD and a half-order dependency in the initiator 4-methylbenzyl alcohol is developed. Additionally, a negative observed reaction rate (k _obs) was determined with increasing the initial monomer concentration, initiator or catalyst, or, surprisingly, decreasing the reaction temperature, giving rise to negative activation energies within the chemical space studied.

Palabras clave:

polimerización por apertura de anillo l-lactida organocatálisis cribado de alto rendimiento cinética ley de velocidad energía de activación plataforma de flujo polímeros biodegradables polímeros de ácido láctico

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