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Videos de Conceptos Relacionados

Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

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Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
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Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

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Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
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Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Lipid Catabolism01:25

Lipid Catabolism

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Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
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Atherosclerosis III: Management01:26

Atherosclerosis III: Management

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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

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Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
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Bone phenotype of patients with genetic forms of lipodystrophy: a systematic review of literature.

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Size-Resolved Lipoprotein Fatty Acid Content as a Novel Nuclear Magnetic Resonance-Derived Trait Specifically Associates with Genetic Variants That Control Fatty Acid Metabolism.

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Control of lipid metabolism in chondrocytes is critical for skeletal growth.

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Video Experimental Relacionado

Updated: Jan 18, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

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Mapeo de Lipoproteínas Impulsado por Ratios Refina las Vías Genéticas del Riesgo Cardiometabólico

S Hani Najafi-Shoushtari, Karsten Suhre, Murugan Subramanian

    Research square
    |January 16, 2026
    PubMed
    Resumen

    Este estudio realizó un mapeo fino de loci de riesgo genético para lípidos sanguíneos desregulados utilizando datos del UK Biobank. Se identificaron nuevos marcadores basados en ratios, revelando nuevas perspectivas sobre el metabolismo de las lipoproteínas y posibles dianas farmacológicas para enfermedades cardiovasculares.

    Palabras clave:
    metabolismo de lipoproteínasenfermedad cardiovasculargenéticametabolómicaUK Biobankhiperlipidemiadiana farmacológica

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    Área de la Ciencia:

    • Genética
    • Metabolómica
    • Investigación de Enfermedades Cardiovasculares

    Sus antecedentes:

    • Los lípidos sanguíneos desregulados son predictores clave de eventos cardiovasculares.
    • Los estudios de asociación del genoma completo (GWAS) han identificado numerosas regiones genómicas relacionadas con el metabolismo de los lípidos.
    • La traducción de asociaciones genéticas en aplicaciones clínicas requiere la comprensión de las funciones génicas en el metabolismo, transporte y remodelación de lipoproteínas (LPmtr).

    Objetivo del estudio:

    • Realizar un mapeo molecular profundo de los loci de riesgo de lípidos utilizando rasgos relacionados con las lipoproteínas y sus ratios.
    • Identificar nuevos marcadores basados en ratios para las vías de LPmtr.
    • Generar nuevas hipótesis para el desarrollo de dianas farmacológicas y descubrir mecanismos en la hiperlipidemia.

    Principales métodos:

    • Mapeo molecular profundo de 554 loci de riesgo de lípidos utilizando 168 rasgos relacionados con lipoproteínas y sus ratios en 273.000 participantes del UK Biobank.
    • Análisis de marcadores basados en ratios, incluyendo la fracción de ácido linoleico, el colesterol esterificado en LDL y la fracción de HDL del número total de partículas de lipoproteínas.
    • Agrupación impulsada por ratios, ensayos celulares integrados y estudios en ratones para investigar funciones y vías génicas.

    Principales resultados:

    • Se identificaron nuevos marcadores basados en ratios para las vías de LPmtr, vinculando loci genéticos con funciones biológicas específicas.
    • Se descubrieron genes causales potenciales en loci de riesgo de lípidos poco caracterizados.
    • Se demostró la utilidad del mapeo fino de lipoproteínas para generar hipótesis de dianas farmacológicas y descubrir mecanismos de hiperlipidemia.
    • Se implicó a miR-148 en la secreción de TG y respuestas al estrés del ER, vinculándolos al metabolismo de VLDL a través de mTORC1.
    • Se identificó miR-148a como un determinante de los niveles de Lp(a).

    Conclusiones:

    • El mapeo fino de lipoproteínas utilizando datos metabolómicos y GWAS proporciona información novedosa sobre la biología de las partículas de lipoproteínas.
    • La evaluación del tamaño y la composición de las lipoproteínas es crucial para comprender, prevenir y tratar los trastornos relacionados con los lípidos.
    • El estudio genera nuevas hipótesis para el desarrollo de dianas farmacológicas en enfermedades cardiovasculares e hiperlipidemia.