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KDASDB: Una base de datos completa y fácil de usar de empalme alternativo dedicada a las enfermedades renales
Yalan Kuang1,2, Yilong Chen1,2, Yongsan Yang1,2
1West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Computational and structural biotechnology journal
|January 16, 2026
Resumen
Una nueva base de datos, KDASDB, cataloga más de 90.000 eventos de empalme alternativo (ASE) en enfermedades renales. Este recurso ayuda a los investigadores a comprender los mecanismos de la enfermedad y a desarrollar nuevos tratamientos.
Área de la Ciencia:
- Genómica
- Biología Molecular
- Bioinformática
Sus antecedentes:
- La enfermedad renal representa un desafío significativo para la salud pública.
- El empalme alternativo (AS) juega un papel crítico en la patogénesis de las enfermedades renales.
- Actualmente no hay una base de datos completa para los eventos de AS asociados con enfermedades renales.
Objetivo del estudio:
- Desarrollar una base de datos dedicada a las enfermedades renales y los eventos de empalme alternativo (ASE).
- Proporcionar una plataforma para explorar los patrones de AS y su significado biológico en las enfermedades renales.
Principales métodos:
- Se integraron 90.273 eventos de empalme alternativo (ASE) de 2406 muestras.
- Se cubrieron 29 enfermedades renales distintas en modelos humanos y de ratón.
- Se identificaron transcritos y ASE novedosos utilizando enfoques bioinformáticos.
Principales resultados:
- Se desarrolló la Base de Datos de Empalme Alternativo de Enfermedades Renales (KDASDB).
- La base de datos incluye 52.478 transcritos humanos novedosos y 41.818 transcritos de ratón novedosos.
- Se descubrieron 3354 ASE humanos novedosos y 5638 ASE de ratón novedosos.
Conclusiones:
- KDASDB proporciona un recurso valioso para estudiar los mecanismos de las enfermedades renales.
- La base de datos facilita la exploración de eventos de AS en la investigación de enfermedades renales.
- KDASDB apoya el descubrimiento de nuevas estrategias terapéuticas para las enfermedades renales.
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