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Informe de caso: Tenecteplasa para accidente cerebrovascular isquémico agudo después de la reversión de la heparina
Manali Desai1, Ameen Fahad1, Kristi Anderson1
1College of Medicine-Jacksonville, University of Florida, Jacksonville, FL, United States.
Frontiers in stroke
|January 16, 2026
Resumen
La tenecteplasa, un fármaco para disolver coágulos, se utilizó de forma segura y eficaz en un paciente que recibía heparina para un accidente cerebrovascular isquémico agudo después de la reversión de la heparina. Este caso demuestra una opción de tratamiento potencial para pacientes con accidente cerebrovascular en tratamiento anticoagulante.
Área de la Ciencia:
- Neurología
- Cardiología
- Farmacología
Sus antecedentes:
- La trombólisis intravenosa es un tratamiento clave para el accidente cerebrovascular isquémico agudo.
- Los pacientes con infusiones de heparina plantean un desafío para la trombólisis debido al riesgo de sangrado.
- La alteplasa ha demostrado seguridad en este escenario, pero el uso de tenecteplasa está aumentando.
Objetivo del estudio:
- Informar sobre el uso seguro y eficaz de tenecteplasa en un paciente anticoagulado con heparina.
- Abordar la brecha en la literatura sobre la eficacia de tenecteplasa después de la reversión de la heparina.
Principales métodos:
- Un informe de caso que detalla la administración de tenecteplasa después de la reversión de la heparina con sulfato de protamina.
- Monitorización de complicaciones hemorrágicas y resultados neurológicos.
Principales resultados:
- Administración intravenosa exitosa de tenecteplasa después de la reversión de la heparina.
- No se observaron complicaciones hemorrágicas.
- El paciente logró un excelente resultado neurológico.
Conclusiones:
- La tenecteplasa intravenosa se puede administrar de forma segura y eficaz a pacientes con accidente cerebrovascular isquémico agudo anticoagulados con heparina después de la reversión.
- Este caso apoya el uso potencial de tenecteplasa en una población más amplia de pacientes con accidente cerebrovascular.
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