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Infección gingival necrosante por Trichoderma longibrachiatum en un receptor de trasplante de células madre

Eduardo Aparicio-Minguijón¹, Nieves López-Muñoz², Pilar Martínez-Sánchez^2,3

¹Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Centro de Actividades Ambulatorias, 6ª planta, Bloque D. Glorieta de Málaga, 11., Madrid 28041, Spain.

Therapeutic advances in infectious disease

|January 16, 2026

Abstract:

Trichoderma is a genus of rare filamentous fungi that can cause invasive fungal infections in immunocompromised patients. We report a case of necrotizing gingival and sinus infection due to T. longibrachiatum in an allogeneic stem cell transplant recipient. The patient received a combination of antifungal and aggressive surgical debridement, achieving clinical cure. The treatment included amphotericin B, voriconazole and caspofungin with the latter switch to rezafungin to consolidate therapy. Rezafungin might represent a useful alternative for fungal infections with limited therapeutic options, but further studies are needed to confirm its role in Trichoderma spp. infections.

Palabras clave:

HSCT Trichoderma longibrachiatum reporte de caso infección fúngica invasiva gingivitis necrosante

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