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Ingeniería de Células T con CAR Totalmente Humanas Optimizadas para la Funcionalidad B7-H3 para una Terapia Mejorada

Pradip Bajgain, Yang Feng, Mariela Puebla

    bioRxiv : the preprint server for biology
    |January 16, 2026
    PubMed
    Resumen

    Se desarrollaron anticuerpos totalmente humanos específicos de B7-H3 para la terapia de células T con receptores de antígenos quiméricos (CAR). Estas nuevas células T con CAR demostraron una eficacia y seguridad superiores en modelos de tumores sólidos en comparación con las terapias existentes.

    Palabras clave:
    terapia de células T con CARB7-H3tumores sólidosanticuerpos totalmente humanosinmunogenicidadingeniería de proteínasoncologíabiotecnología

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