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Candida auris puede adquirir resistencia a los antifúngicos sin presión de selección

Trinh Phan-Canh, Duc-Minh Nguyen-Le, Manju Chauhan

bioRxiv : the preprint server for biology

|January 16, 2026

Resumen

Candida auris puede desarrollar resistencia a los medicamentos y cambiar de forma durante el envío de laboratorio, incluso sin exposición a antifúngicos. Esto destaca la necesidad de protocolos estandarizados al intercambiar cepas clínicas entre laboratorios de micología.

Sus antecedentes:

Candida auris es un patógeno fúngico humano importante que causa brotes con alta mortalidad.
Los fallos en el tratamiento están relacionados con la resistencia a los medicamentos antifúngicos y la variabilidad de las cepas.
La variabilidad intraespecífica y la hipermutación inducida contribuyen a la patogenicidad y al fallo del tratamiento.

Conclusiones:

Candida auris puede adquirir mutaciones que afectan la resistencia a los medicamentos sin exposición a antifúngicos.
El manejo y intercambio rutinario de cepas puede conducir a una diversificación genética y fenotípica significativa.
Los protocolos estandarizados para el intercambio de cepas clínicas de C. auris son cruciales para la investigación y el diagnóstico fiables.

Palabras clave:

Candida auris resistencia a los antifúngicos resistencia a los medicamentos morfotipos intercambio de cepas mutaciones genéticas estabilidad genética

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