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B7-H3 upregulation in ischemic stroke: friend or foe?

Siva Reddy Challa, Isidra M Baker, Casimir A Fornal

bioRxiv : the preprint server for biology

|January 16, 2026

Resumen

B7-H3 (CD276) expression increases in the brain after ischemic stroke, correlating with inflammation. This immune checkpoint molecule

Sus antecedentes:

B7-H3 (CD276) es una molécula de punto de control inmunitario que se sabe que influye en las respuestas de las células T y la inflamación.
Su papel en el accidente cerebrovascular isquémico no se comprende bien, a pesar de su regulación al alza en otras afecciones neuroinflamatorias.

Conclusiones:

B7-H3 es una molécula de punto de control inmunitario inducida por isquemia en el cerebro.
Su perfil de expresión sugiere un papel en la modulación de la neuroinflamación post-accidente cerebrovascular.
Se necesita más investigación para aclarar los roles específicos y el potencial terapéutico de B7-H3 en la I/R cerebral.

Palabras clave:

B7-H3 CD276 ischemic stroke inflammation neuroinflammation immune checkpoint molecule therapeutic target

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