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Restarting Stalled Replication Forks02:37

Restarting Stalled Replication Forks

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DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart,...
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Restarting Stalled Replication Forks02:37

Restarting Stalled Replication Forks

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The DNA Replication Fork01:02

The DNA Replication Fork

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An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication...
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The DNA Replication Fork01:02

The DNA Replication Fork

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Replication in Eukaryotes01:29

Replication in Eukaryotes

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In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
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Replication in Eukaryotes02:31

Replication in Eukaryotes

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Video Experimental Relacionado

Updated: Jan 18, 2026

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
07:27

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

Published on: April 29, 2010

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Condensación impulsada por PAR mantiene la estabilidad de las horquillas de replicación detenidas

Lei Zhang, Zeyu Zhang, Timothy R O'Leary

    bioRxiv : the preprint server for biology
    |January 16, 2026
    PubMed
    Resumen
    Este resumen es generado por máquina.

    La poli(ADP-ribosa) (PAR) forma condensados nucleares cuando se inhibe el proteasoma, co-condensándose con cadenas de ubiquitina y proteasomas. Estas estructuras protegen la integridad genómica al estabilizar las horquillas de replicación detenidas.

    Palabras clave:
    poli(ADP-ribosa)condensados nuclearesestrés proteasomalintegridad genómicahorquillas de replicación detenidasubiquitinaproteasomaPARP2ubicuitinación ligada a K6separación de fases líquido-líquido

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