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Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
Published on: October 16, 2013
Sistema novedoso de puntuación de dificultad para la disección endoscópica submucosa en el cáncer gástrico temprano
Zhilin Liu1, Linfu Zheng1,2, Xingjie Gao1
1Department of Gastroenterology, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China.
Background/Aim:
Endoscopic submucosal dissection (ESD) for early gastric cardiac cancer (EGCC) faces anatomical challenges. This study aims to develop and validate a predictive model for ESD difficulty in EGCC, providing a basis for matching difficulty levels with endoscopists' experience.
Methods:
This multicenter retrospective study included 514 EGCC patients from five tertiary hospitals (2017-2025). Patients from the 900th Hospital were randomized to training (n = 206) and internal validation (n = 164) cohorts; four other hospitals formed an external cohort (n = 144). Predictors with high collinearity (VIF ≥ 5) were excluded. Predictor selection was performed using LASSO regression, followed by multivariable logistic regression. Model performance was assessed using ROC curves, calibration plots, and decision curve analysis (DCA).
Results:
The clinical scoring model incorporated four factors: Paris type III lesion (3 points), maximum diameter ≥3 cm (1 point), submucosal invasion (5 points), and lesion located on the anterior wall of the cardia (3 points). Model performance demonstrated an AUC of 0.784 (95% CI, 0.695-0.876) in the training cohort, 0.762 (95% CI, 0.653-0.884) in internal validation, and 0.740 (95% CI, 0.636-0.845) in external validation. Difficulty stratification was defined as: easy (0, 1, or 3 points), intermediate (4, 5, or 6 points), and difficult (8 or 11 points).
Conclusion:
This validated system optimizes endoscopist matching, reducing costs and recurrence in EGCC ESD.
