Estructura y biospeciación en solución de complejos de tricarbonilrenio(I) de mercaptopirimidinas con actividad...

Área de la Ciencia:

• Organometallic Chemistry
• Medicinal Chemistry
• Bioinorganic Chemistry

Sus antecedentes:

• Development of novel metal-based compounds for therapeutic applications.
• Exploration of rhenium complexes for their unique electronic and biological properties.
• Need for multifunctional agents targeting cancer, viral, and bacterial infections.

Objetivo del estudio:

• Synthesize and characterize novel bidentate (N, N) ligands and their fac-tricarbonylrhenium(I) complexes.
• Evaluate the multifunctional bioactivity, including cytotoxicity, antiviral, and antibacterial effects.
• Investigate the aqueous stability and interactions with biological macromolecules.

Principales métodos:

• Synthesis of four novel bidentate ligands and their corresponding rhenium(I) complexes.
• Characterization using spectroscopic and analytical techniques.
• In vitro assays for cytotoxicity (cancer cell lines), antiviral activity (Herpes simplex virus type 2), and antibacterial activity (Staphylococcus aureus, including MRSA).
• Assessment of aqueous stability, ligand-exchange processes, and interaction with human serum albumin.

Principales resultados:

• Successful synthesis and characterization of fac-[Re(CO)3(N, N)X]n+ complexes.
• Moderate cytotoxicity observed against various human cancer cell lines, with selectivity for Colo205.
• Inhibition of Herpes simplex virus type 2 replication by most chlorido complexes.
• Significant antibacterial activity and biofilm inhibition against Staphylococcus aureus (including MRSA) by ReB4.
• Aqueous decomposition of ReB2 and ReB3 correlated with reduced anticancer activity.
• Ligand exchange of chloride by water observed, impacting solubility and lipophilicity.
• Aqua complex ReB1Aq showed low chloride affinity (pKa ~8) and interacted with human serum albumin via non-covalent forces.

Conclusiones:

• Novel rhenium(I) complexes exhibit promising multifunctional bioactivity, including anticancer, antiviral, and antibacterial properties.
• The observed bioactivity is influenced by ligand structure, aqueous stability, and ligand-exchange processes.
• ReB4 demonstrates potential as an antibacterial agent against resistant strains and for biofilm inhibition.
• Understanding the behavior of these complexes in aqueous media and their protein interactions is crucial for further development.