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Updated: May 10, 2026
Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
Published on: August 31, 2019
Desarrollo de nanopartículas de prolaminina de mijo de cola de zorro cargadas con naringenina modificadas con ácido
Wen Zhang1, Wenjing Liang2, Zhizhe Zhang2
1Tianjin Key Laboratory of Food Science and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China; Key Laboratory of Low Carbon Cold Chain for Agricultural Products, Ministry of Agriculture and Rural Affairs, China.
Abstract:
The limited solubility and bioavailability of Naringenin (Nar) require the development of efficient delivery systems. Herein, Naringenin-loaded foxtail millet prolamin nanoparticles (Nar-FP NPs) were synthesized via antisolvent precipitation and surface-modified with hyaluronic acid (HA) to form Nar-FP-HA NPs. Under optimized FP:Nar ratio (5:1, w/w) and HA concentration (2 mg/mL), the nanoparticles displayed minimal particle size (177.40 ± 0.87 nm) and high zeta-potential (-26.37 ± 1.01 mV). The formation of Nar-FP-HA NPs was primarily driven by electrostatic attractions, hydrogen bonding, and hydrophobic interactions. These nanoparticles achieved high encapsulation efficiency (96.80%) and maintained excellent physical stability under various environmental conditions. Compared to free Nar, Nar-FP-HA NPs displayed enhanced antioxidant activity and remarkably increased bioaccessibility. Furthermore, in vitro release studies confirmed controlled release of Nar under simulated gastrointestinal tract conditions. This study developed an efficient FP-HA-based system for Nar delivery, offering novel strategies for applications in the food and nutritional industries.
