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Muerte Celular Regulada en la EPOC: Moduladores, Mecanismos de Interacción y Oportunidades Terapéuticas

Weibin Ruan¹, Mingsi Huang¹, Xiaohua Li¹

¹Department of Respiratory and Critical Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, 518000, People's Republic of China.

European journal of pharmacology

|January 16, 2026

Resumen

Las vías de muerte celular regulada (RCD) son clave en la patogénesis de la enfermedad pulmonar obstructiva crónica (EPOC). La comprensión de la interconexión de la RCD y la señalización intercelular ofrece nuevas dianas terapéuticas para la EPOC.

Área de la Ciencia:

Medicina Pulmonar
Biología Celular
Inmunología

Sus antecedentes:

La enfermedad pulmonar obstructiva crónica (EPOC) es un trastorno inflamatorio progresivo de las vías respiratorias.
La muerte celular regulada (RCD) juega un papel crucial en la patogénesis de la EPOC.
Los mecanismos de regulación de la RCD, la interconexión de vías y la comunicación intercelular en la EPOC no se comprenden completamente.

Objetivo del estudio:

Revisar las principales vías de RCD (apoptosis, necroptosis, ferroptosis, piroptosis, NETosis, PANoptosis) en la EPOC.
Explorar la regulación de la RCD, la interconexión, la señalización intercelular y el potencial terapéutico en la EPOC.
Elucidar la compleja red de RCD en la EPOC para una mejor comprensión y terapias de precisión.

Principales métodos:

Revisión de la literatura actual sobre las vías de RCD en la EPOC.
Análisis de la regulación de la RCD a través de receptores, epigenética y modificaciones postraduccionales.
Examen de la comunicación intercelular mediada por RCD, incluida la señalización de exosomas y la liberación de ADN extracelular.

Principales resultados:

Las vías de RCD están intrínsecamente reguladas por el estrés del RE, el estrés oxidativo y la autofagia.
La interconexión entre las vías de RCD y la señalización intercelular mediada por RCD contribuye significativamente a la inflamación de la EPOC.
Las estrategias terapéuticas dirigidas a las vías de RCD muestran ser prometedoras para el tratamiento de la EPOC.

Conclusiones:

Descifrar la red de RCD en la EPOC es esencial para comprender la heterogeneidad de la enfermedad.
Dirigirse a las vías de RCD ofrece una vía prometedora para desarrollar terapias de precisión para la EPOC.
Una mayor investigación sobre los mecanismos de RCD puede conducir a nuevas estrategias de tratamiento para la EPOC.

Palabras clave:

EPOC microbioma de las vías respiratorias epigenética compuestos naturales muerte celular regulada células madre

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