Video Experimental Relacionado

Updated: Jan 18, 2026

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

Published on: January 21, 2020

Catálisis de Paladio(II) para la Aciloxilación Directa en C7 de Indoles

Xianyu Zhang¹, Jingwen Wang¹, Shengrong Chen¹

¹State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350116, China.

Organic letters

|January 16, 2026

Abstract:

We report a palladium-catalyzed C-H acyloxylation of indoles that achieves excellent regioselectivity at the C7 position. The synergistic combination of a methylsulfonyl directing group and a pyridone-based ligand was crucial to overriding the inherent preference for functionalization at the C3 position. The reaction features a broad substrate scope and good functional group tolerance and provides direct access to valuable 7-acyloxylated indole derivatives.

Palabras clave:

indoles aciloxilación catálisis paladio química orgánica química medicinal regioselectividad grupo director ligando

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