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Updated: Jan 18, 2026

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Factores de riesgo y resultados clínicos asociados con la calcificación del anillo mitral en la miocardiopatía

Bowen Guo¹, Bangrong Song¹, Xiaoyu Xu²

¹Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University Beijing, People's Republic of China.

Expert review of clinical pharmacology

|January 16, 2026

Abstracto

Objective:

This study aimed to identify risk factors associated with mitral annular calcification (MAC) in patients with hypertrophic obstructive cardiomyopathy (HOCM) and to evaluate its relationship with clinical outcomes.

Methods:

A total of 310 patients with HOCM who underwent interventricular septal myectomy were retrospectively analyzed. Patients were divided into a MAC group (n = 24) and a non-MAC group (n = 286). Demographic characteristics, echocardiographic parameters, and clinical data were compared between groups. Major adverse cardiovascular and cerebrovascular event (MACCE) and circulating levels of brain natriuretic peptide, Apelin, and Galectin-3 were analyzed.

Results:

Patients with MAC were older and showed higher prevalence of aortic annular calcification, mitral leaflet thickening, and moderate-to-severe tricuspid regurgitation (P < 0.05). Multivariate analysis identified gender, age, aortic annular calcification, moderate-to-severe tricuspid regurgitation, and mitral leaflet thickening as independent risk factors for MAC. Patients with MAC showed larger left ventricular end-diastolic volume, reduced left ventricular ejection fraction, and greater left atrium mass, and a higher incidence of MACCE than those without MAC (P < 0.05).

Conclusion:

In HOCM undergoing septal myectomy, MAC is associated with adverse cardiac remodeling and unfavorable clinical outcomes. Identification of related factors may aid risk stratification and perioperative management.

Palabras clave:

miocardiopatía hipertrófica obstructiva función cardíaca calcificación del anillo mitral pronóstico factores de riesgo

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