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Áreas de investigación Ciencias Biomédicas y Clínicas Medicina cardiovascular y hematología Cardiología (incluidas enfermedades cardiovasculares)
Áreas de investigación
Ciencias Biomédicas y Clínicas
Medicina cardiovascular y hematología
Cardiología (incluidas enfermedades cardiovasculares)
La genética humana guía el descubrimiento de inhibidores de CARD9 con actividad antiinflamatoria

La genética humana guía el descubrimiento de inhibidores de CARD9 con actividad antiinflamatoria

Jason S Rush ¹, Joshua D Wertheimer ², Steven D Goldberg ³, Donald Raymond ¹, Mateusz Szuchnicki ¹, Andrew J Baltus ², Jeff Branson ², Christopher F Stratton ², Aaron N Patrick ², Ruth Steele ², Suraj Adhikary ², Amanda Del Rosario ², Annie Liu ², Noah J Gomersall ², Michael Chung ³, Matthew J Ranaghan ¹, Xiebin Gu ⁴, Marta Brandt ⁵, Zhifang Cao ⁵, Adrian Bebenek ⁶, Blayne A Oliver ⁴, Kasper Hoebe ², Lawrence M Szewczuk ², Jennifer D Venable ³, Daniel B Graham ⁷, Jennifer Towne ³, Ramnik J Xavier ⁷

Jason S Rush ¹, Joshua D Wertheimer ², Steven D Goldberg ³

¹Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
²Johnson & Johnson Innovative Medicine, Spring House, PA 19477, USA.
³Johnson & Johnson Innovative Medicine, San Diego, CA 92121, USA.
⁴Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
⁵Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
⁶Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Chemical Biology PhD Program, Harvard Medical School, Boston, MA 02115, USA.
⁷Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

⁰Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Cell +

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17 de enero de 2026

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17 de enero de 2026

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Resumen

No abstract available on PubMed

Palabras clave:

La enfermedad de Crohn Primero el aglutinante. bobina enrollada descubrimiento de fármacos inmunidad a los hongos Enfermedad mediada por la inmunidad inmunidad innata Algunas señales inhibidor de moléculas pequeñas

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