Video Experimental Relacionado

Updated: Jan 20, 2026

Force and Position Control in Humans - The Role of Augmented Feedback

Force and Position Control in Humans - The Role of Augmented Feedback

Published on: June 19, 2016

La mutación KRAS^G12/13 modula los resultados del CCRC al alterar la retroalimentación positiva entre macrófagos y

Xuehan Yan¹, Juncheng Su¹, Hongyuan Liu²

¹Department of Gastrointestinal Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

|January 19, 2026

Abstract:

Kirsten rat sarcoma viral oncogene (KRAS) mutation influences colorectal cancer (CRC) progression, but their specific impact on the tumor immune microenvironment remains poorly defined. This study establishes that KRAS^G12/13 mutation disrupts critical positive feedback between macrophages and CD4⁺ T cells. Mechanistically, KRAS^G12/13-mutant tumor cells secrete elevated interleukin-10 (IL-10), which suppresses macrophage production of chemokine ligand 9/10 (CXCL9/10) and major histocompatibility complex II (MHC-II). This impairs the infiltration and activation of CXCR3⁺CD4⁺ T cells, fostering an immunosuppressive niche. By integrating multi-omics data from clinical cohorts and validating findings in vivo, we show that combining KRAS inhibitors with CXCL9/10 restoration effectively overcomes this immune suppression and controls tumor growth. Our work delineates a targetable immune evasion mechanism and provides a cohesive prognostic and therapeutic framework for KRAS^G12/13-mutant CRC.

Palabras clave:

ciencias de la salud

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