Video Experimental Relacionado

Updated: Jan 20, 2026

Amino acids: Structure, Classification, D- & L-Isomers

Amino acids: Structure, Classification, D- & L-Isomers

Síntesis secuencial en un solo paso de 1,3,5-triazinas diversamente funcionalizadas a través de cloruro de cianurilo

Shaoren Yuan¹, Moustafa T Gabr¹

¹Department of Radiology, Molecular Imaging Innovations Institute (MI3), Weill Cornell Medicine, New York, New York 10065, United States.

|January 19, 2026

Abstract:

A cyanuric chloride-mediated sequential one-pot strategy enables the rapid construction of trisubstituted 1,3,5-triazines via three C-N or two C-N with one C-C bond formations. By delicately designing the sequence of reagent addition, this operationally simple protocol exhibits broad functional group tolerance across 22 examples (34-69% yield) performed from milligram to subgram quantities and demonstrates future derivatizations. Finally, the synthetic utility is highlighted by the successful synthesis of the FDA-approved anticancer drug Enasidenib.

Palabras clave:

síntesis en un solo paso cloruro de cianurilo 1,3,5-triazinas química medicinal síntesis orgánica ácidos borónicos grupos amino Enasidenib

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