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Expresión aberrante de marcadores CD en pacientes con leucemia aguda
Aymen Radhi Habeeb1, Hamid Al-Tameemi2, Dina A A Abdullah3
1DIRECTORATE OF EDUCATION OF RASAFA, MINISTRY OF EDUCATION, IRAQ.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
|January 19, 2026
Resumen
Este estudio encontró altas tasas de expresión anormal de marcadores de Cluster of Differentiation (CD) en pacientes iraquíes con leucemia. La inmunofenotipificación de estos antígenos aberrantes es crucial para el diagnóstico de la leucemia.
Área de la Ciencia:
- Hematología; Inmunología; Oncología
Sus antecedentes:
- El diagnóstico de leucemia se basa en la identificación de marcadores celulares específicos.; Los marcadores de Cluster of Differentiation (CD) son clave en la clasificación de los subtipos de leucemia.; La comprensión de los patrones de expresión de los marcadores CD es vital para un diagnóstico y tratamiento precisos.
Objetivo del estudio:
- Evaluar la prevalencia de la expresión anormal de marcadores de Cluster of Differentiation (CD) en pacientes iraquíes con leucemia (AL).; Analizar la expresión de marcadores CD en pacientes con leucemia recién diagnosticados.; Correlacionar los perfiles inmunofenotípicos con los subtipos de leucemia.
Principales métodos:
- Inclusión de 175 pacientes con leucemia recién diagnosticados (110 hombres, 65 mujeres; de 1 a 85 años).; Aspiración de médula ósea y citometría de flujo para el análisis de marcadores CD.; Análisis estadístico de parámetros hematológicos, perfiles inmunofenotípicos y datos demográficos.
Principales resultados:
- Se identificó expresión aberrante de CD13, CD19, CD33, CD34, CD117, CD56, CD5, TdT, HLA-DR y CD79a.; La leucemia mieloide aguda (LMA) fue el subtipo más común (46,2%), seguida de la leucemia linfoide aguda de células B (LLA-B) (26,2%) y la leucemia linfoide aguda de células T (LLA-T) (8,5%).; CD34 mostró alta expresión en LMA, LLA-B y LLA-T; CD13 y CD33 fueron predominantes en LMA; CD56 y CD117 se relacionaron con mieloma múltiple (MM).
Conclusiones:
- Se observó una alta proporción de expresión anormal de marcadores CD en casos de leucemia.; La inmunofenotipificación ayuda en el diagnóstico de la leucemia y la diferenciación de células neoplásicas de células normales.; Los hallazgos concuerdan con datos globales sobre la expresión de antígenos aberrantes en la leucemia.
Palabras clave:
Marcadores CDexpresión aberranteleucemia agudacitometría de flujoinmunofenotipificaciónMás Videos Relacionados
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